Endocrine Abstracts

Background: Ectopic malignancies arising from adrenal rests are extremely rare. Localization has been reported in the retroperitoneum, testis/scrotum, ovary, kidney, anterior abdominal wall, spinal cord, and liver associated with embryological development 1-3.Objective: This report presents a case of ectopic adrenocortical cancer (ACC) localized to the pancreas. An exciting feature of the case was the simultaneous presence of breast cancer.</p...

Aim: Hashimoto Thyroiditis (HT); is the most common form of hpothyroidism in iodine-sufficient regions. Both genes and and environmental factors are involved in the immunopathological process of HT. Our aim in this study is to determine the prevalence of Thyrothropin Receptor (TSHR), Cytotoxic T Lypmhocyte Antigen-4 (CTLA-4) and Interleukin-1 Receptor Antagonist (IL-1RN) gene polymorphisms associated with HT in Turkish population and the relationship of genotype characteristic...

Introduction: Ectopic adrenocorticotrophic hormone (ACTH) syndrome is associated with variable tumor groups most commonly originating from neuroendocrine cells. Here, we reported a patient considered to have nonconvulsive status epilepticus initially due to neurological symptoms and diagnosed as neuroendocrine tumor with ectopic ACTH syndrome.Case: A 85 years old woman with regulated hypertension admitted with partial loss of conciousness. She had cachec...

Objectives: Preoperative imaging studies are being commonly used in primary hyperparathyroid patients to increase cure rate and to decrease complication rate of surgery. In this study we correlated the surgical outcomes with localization studies performed by various radiologists.Method: A total of 174 patients with primary hyperparathyroidism in which healing of hypercalcemia achieved by parathyroidectomy were evaluated retrospectively. Since our hospita...

Introduction: Traumatic brain injury (TBI) is a worldwide public health problem and has been recently documented as a cause of neuroendocrine dysfunction. It has been shown that hypopituitarism may develop nearly 10–20% of the TBI patients, and most common pituitary hormone deficiency after TBI is growth hormone deficiency (GHD). To date no study has evaluated the relation between isolated maxillofacial fractures and pituitary dysfunction. Therefore we aimed to investigat...

Androgenic alopecia (AGA) is an important clinical issue that can cause significant cosmetic problems. Many factors such as genetic, androgen hormones, environmental factors, and inflammation are involved in the pathogenesis of androgenic alopecia. Insulin and insulin resistance have been found increased in individuals with AGA. There are many proinflammatory substances which are playing role in the pathogenesis of androgenic alopecia. Secreted frizzled related protein-4 (SFRP...

Introduction: Patients with hypogonadism are at increased risk for cardiovascular diseases. Mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) are hematological indices that are surrogate markers of adverse cardiovascular outcomes. This study investigated the platelet count, MPV levels, PLR, and NLR in patients with congenital hypogonadotrophic hypogonadism (CHH) and also studied the effect of testosterone replacement thera...

Macro TSH is a large molecular-sized thyroid-stimulating hormone (TSH) that is including TSH and anti-TSH antibody. Patients with macro TSH have elevated serum TSH and normal free thyroxine levels similar to subclinical hypothyroidism. A 18-year old female patient was referred from gynecology and obstetrics to endocrinology clinic for evaluating of elevated TSH with normal free thyroxine levels. Laboratory and clinical investigations revealed that only discordant TSH levels (n...

IntroductionGlucagonoma is an extremely rare type of functional pancreatic neuroendocrine tumor that is characterized by distinctive clinical manifestations such as diabetes mellitus, weight loss, deep vein thrombosis, and necrolytic migratory erythema which represents the hallmark clinical sign of glucagonoma syndrome. Here, we report the case of a 53-year-old male patient who presented with high amilase and lipase levels. In further investigation a pan...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare, heritable syndrome characterized by a hyperparathyroidism, pituitary adenoma and pancreatic islet cells.Case: A 56-year-old male patient had a single parathyroid excised for primary hyperparathyroidism 10 years ago. He was further investigated due to hypoglycemia and a mass was found in the head of the pancreas on MRI. It was reported as neuroendocrine tumor and no recurrence was found i...